Treatment Sometimes, treating an underlying condition, such as iron deficiency, greatly relieves symptoms of RLS. Correcting an iron deficiency may involve receiving iron supplementation orally or intravenously. However, take iron supplements only with medical supervision and after your provider has checked your blood-iron level. If you have RLS without an associated condition, treatment focuses on lifestyle changes. If those aren't effective, your provider might prescribe medications. Medications Several prescription medications, most of which were developed to treat other diseases, are available to reduce the restlessness in the legs. These include: • Medications that increase dopamine in the brain. • Drugs affecting calcium channels. • Muscle relaxants and sleep medications