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Testing and diagnosis of MOG Antibody Disease Diagnosing MOGAD quickly and correctly is critical. Patients who show the symptoms listed above will undergo a serum blood test. The diagnosis of MOGAD is confirmed if the test comes back clearly positive for MOG antibodies. MRIs of the brain, orbits and spine may also reveal lesions or white matter changes suggestive of an inflammatory process. As appropriate, our Neuroimmune specialists will also rule out other conditions that may look similar to MOG antibody disease. Diagnostic tests include: Lumbar puncture (spinal tap) Laboratory blood test Magnetic resonance imaging (MRI) #mog #myelin #myelinsheath