Dr. Advait Kulkarni (neurologist in Bengaluru) Multiple sclerosis (MS) is a potentially disabling disease of the brain and spinal cord (central nervous system). SYMPTOMS Multiple sclerosis signs and symptoms may differ greatly from person to person and over the course of the disease depending on the location of affected nerve fibers. Symptoms often affect movement, such as: • Numbness or weakness in one or more limbs that typically occurs on one side of your body at a time, or your legs and trunk • Electric-shock sensations that occur with certain neck movements, especially bending the neck forward (Lhermitte sign) • Tremor, lack of coordination or unsteady gait Vision problems are also common, including: • Partial or complete loss of vision, usually in one eye at a time, often with pain during eye movement • Prolonged double vision • Blurry vision Multiple sclerosis symptoms may also include: • Slurred speech • Fatigue • Dizziness • Tingling or pain in parts of your body • Problems with sexual, bowel and bladder function