Alzheimer's disease (AD) involves a comprehensive assessment that integrates clinical evaluations, cognitive testing, and biomarker analyses. Recent advancements have refined these protocols to enhance diagnostic accuracy. 1. Clinical Evaluation: Medical History: Gathering detailed information on the patient's medical history, including cognitive and behavioral changes, family history of dementia, and other relevant factors. 2. Physical and Neurological Examination: Assessing neurological function to rule out other conditions that may mimic AD symptoms. Differential Diagnosis: It's crucial to distinguish AD from other dementias, such as Limbic-predominant Age-related TDP-43 Encephalopathy (LATE), which shares similar clinical features but requires different management strategies. These internationally accepted protocols aim to improve early and accurate diagnosis of Alzheimer's disease, facilitating timely interventions and better patient outcomes. Advance Diagnosis of Alzheimer's Disease: Recent diagnostic protocols for AD emphasize the integration of clinical evaluations, cognitive testing, and biomarker analyses. Key advances include: Neuroimaging: PET scans to detect amyloid plaques and tau tangles. MRI for assessing structural changes in the brain. Biomarker Testing: Cerebrospinal fluid (CSF) analysis for amyloid-beta and tau protein levels. Blood-based biomarker tests, emerging as less invasive alternatives. Cognitive Assessments: Tools such as the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE). If you or a loved one notice symptoms like Alzheimer's Disease or symptoms changes, consult a neurologist promptly. Early care can make a meaningful difference. Dr. Advait Kulkarni (Neurologist, MBBS, DM) www.dradvaitkulkarni.com #neurology #healthandwellness #awarness #healthyliving